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省級研究所(中心):河北省心腦血管病防治協(xié)同創(chuàng)新中心

河北省心腦血管病防治協(xié)同創(chuàng)新中心簡介

Hebei Collaborative Innovation Center for Cardio-cerebral Vascular Disease

心腦血管病是造成國人死亡的第一原因,是危害人類健康的主要疾病。“河北省心腦血管病防治協(xié)同創(chuàng)新中心”(以下簡稱“中心”)的建立始于2012年3月15日由教育部和財政部實施的“高等學校創(chuàng)新能力提升計劃”(即“2011計劃”)。“中心”以降低心腦血管病發(fā)病率、提高人民健康水平為目的,以創(chuàng)新能力提升為突破,在基礎科學研究之上,以協(xié)同創(chuàng)新、科研成果的快速臨床轉化為工作重點,積極開展“原創(chuàng)性、前瞻性和應用性”研究,努力為我省乃至國家的心腦血管病防治提供強有力的理論支撐,人才保障和智力支持。

“中心”由三個國家臨床重點??平ㄔO項目——河北醫(yī)科大學第二醫(yī)院神經內科、心血管內科和心臟大血管外科牽頭,聯合河北省神經病學重點實驗室、河北省心腦血管病研究所、山東第一醫(yī)科大學(原泰山醫(yī)學院)動脈粥樣硬化研究所、河北醫(yī)科大學病理生理及生理教研室(河北省重點學科)、國家著名心腦血管病藥物研發(fā)企業(yè)——石藥集團、河北省疾病預防控制中心、同時聯合省內11個設區(qū)市三級甲等醫(yī)院的心腦血管病診療研究機構和相關臨床科室,瞄準國際前沿,服務地方,凝練4大協(xié)同創(chuàng)新方向:①心腦血管病關鍵病例機制研究與臨床治療策略探討;②創(chuàng)新心腦血管病治療模式,提高治愈率、降低殘疾率;③心腦血管病新藥研發(fā)與有效藥物篩選;④心腦血管病聯合防控體系建設。打造國內一流、多學科合作、優(yōu)勢互補的綜合平臺,匯聚在國際學術界有重大影響力的著名專家學者為平臺負責人,領導核心團隊開展前沿性研究工作。

為了集中力量對血管疾病進行系統(tǒng)攻關研究,2015年1月25日,基于河北省心腦血管病防治協(xié)同創(chuàng)新中心、河北醫(yī)科大學第二醫(yī)院及山東第一醫(yī)科大學動脈粥樣硬化研究所而建立“河北省血管穩(wěn)態(tài)重點實驗室”,并于2018年6月8日通過河北省科學技術廳組織的“省級重點實驗室”驗收,已納入省級重點實驗室管理。實驗室具備國際一流的神經血管分析和動態(tài)觀測平臺,配備高精尖儀器設備和頂級數據分析系統(tǒng),并擁有臨床病房作為基地,開展臨床應用研究。

“中心”在建設中獲得了國家自然科學基金,河北省教育廳、財政廳、衛(wèi)健委(原衛(wèi)計委)、科技廳,河北醫(yī)科大學以及石藥集團的大力支持。共建單位前期及成立后共榮獲國家科技進步二等獎3項,國家技術發(fā)明二等獎1項,河北省科技進步一等獎8項,河北省科技進步二等獎11項,河北省科技進步三等獎35項,中國藥學會科學技術三等獎1項。目前已發(fā)表學術論文2538篇,其中SCI論文324篇,其中8篇論文榮獲國家衛(wèi)計委腦防辦百篇優(yōu)秀論文。起草了《中國腦梗死中西醫(yī)結合診治指南2017》,參加撰寫腦血管病指南6部,舉辦腦血管病新進展學習班4期,在全國專業(yè)學術會議大會交流20次。建成了河北省腦血管病分級診療區(qū)域中心-石家莊市17個縣和24個社區(qū)醫(yī)院雙向轉診網絡,是“河北省腦血管病規(guī)范化治療培訓基地”、“河北省疑難腦血管病遠程會診中心”,極大地促進了河北省腦血管病診療水平提升,團隊獲得了“河北省高校李保國式科技服務團隊”。

“中心”本著優(yōu)勢互補、資源共享、互惠互利的原則,歡迎國內外醫(yī)療單位、專家學者積極參與“中心”的協(xié)同創(chuàng)新工作。

河北省心腦血管病防治協(xié)同創(chuàng)新中心的病房在17樓,醫(yī)辦室電話:0311-66636272,護理站電話:0311-66636271;重點實驗室在18樓,聯系電話:0311-66636287。

地址:河北醫(yī)科大學第二醫(yī)院北院區(qū),中華北大街309號

附:近2年SCI論文匯總

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2. Yang Y, Zhang X J, Zhang C, et al. Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice[J]. Neuroscience Letters, 2018, 678:48-54.

3. Chen Y, Jin S, Teng X, et al. Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress[J]. Oxidative Medicine & Cellular Longevity, 2018, 2018:6717212.

4. Yuan F, Wang H, Feng J, et al. Leptin Signaling in the Carotid Body Regulates a Hypoxic Ventilatory Response Through Altering TASK Channel Expression[J]. Frontiers in Physiology, 2018, 9:249.

5. Li G Q, Wang Z, Zhao T, et al. Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats[J]. Journal of Hypertension, 2018, 36(4):1.

6. Feng P, Zhang X, Li D, et al. Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease[J]. Neuropharmacology, 2018, 133:385-394.

7. Congrui M F, Na L, Yujia M Y, et al. Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension[J]. Canadian Journal of Physiology & Pharmacology, 2018, 96(8):807-814.

8. Chen Y, Zhang X, He J, et al. Delayed Administration of the Glucagon-Like Peptide 1 Analog Liraglutide Promoting Angiogenesis after Focal Cerebral Ischemia in Mice[J]. Journal of Stroke and Cerebrovascular Diseases, 2018, 27(5):1318-1325.

9. Qiu X, Liu K, Xiao L, Jin S, Dong J, Teng X, et al. Alpha-lipoic acid regulates the autophagy of vascular smooth muscle cells in diabetes by elevating hydrogen sulfide level[J]. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018;1864(11):3723-3738.

10. Li L, Kang Y X, Ji X M, et al. Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats[J]. CNS Neuroscience & Therapeutics, 2018, 24(2):115-125.

11. Hao W, Yang R, Yang Y, et al. Stellate ganglion block ameliorates vascular calcification by inhibiting endoplasmic reticulum stress[J]. Life Sciences, 2018, 193:1-8.

12. Xiao L, Dong J H, Teng X, et al. Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling[J]. Journal of Hypertension, 2018, 36(3):651.

13. Jin S, Tan B, Teng X, et al. Diurnal Fluctuations in Plasma Hydrogen Sulfide of the Mice[J]. Frontiers in Pharmacology, 2017, 8:682.

14. Jin S, Teng X, Xiao L, et al. Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt/eNOS/NO pathway[J]. Experimental Biology & Medicine, 2017, 242(18):1831-1841.

15. Li H, Teng X, Yang R, et al. Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification[J]. Frontiers in Pharmacology, 2017, 8:629.

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17. Jiao G, Zhang G, Wang H, et al. Glucose Intake Alters Expression of Neuropeptides Derived from Proopiomelanocortin in the Lateral Hypothalamus and the Nucleus Accumbens in Fructose Preference Rats[J]. Neural Plasticity, 2017, 2017(3):1-7.

18. Gao Y, Zhou JJ, Zhu Y, Wang L, Kosten TA, Zhang X, Li DP. Neuroadaptations of presynaptic and postsynaptic GABAB receptor function in the paraventricular nucleus in response to chronic unpredictable stress.Br J Pharmacol. 2017 Sep;174(17):2929-2940.

19. Chen R, Kong P, Zhang F, Shu YN, Nie X, Dong LH, Lin YL, Xie XL, Zhao LL, Zhang XJ, Han M. EZH2-mediated α-actin methylation needs lncRNA TUG1, and promotes the cortex cytoskeleton formation in VSMCs.Gene. 2017 Jun 15;616:52-57.

20. Fu C, Xue J, Wang R, Chen J, Ma L, Liu Y, Wang X, Guo F, Zhang Y, Zhang X, Wang S. Chemosensitive Phox2b-expressing neurons are crucial for hypercapnicventilatory response in the nucleus tractussolitarius.J Physiol. 2017 May 10.

21. Li X, Su L, Zhang X, Zhang C, Wang L, Li Y, Zhang Y, He T, Zhu X, Cui L. Ulinastatindownregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury.Neurol Res. 2017 Apr;39(4):367-373.

22. He W, Cui L, Zhang C, Zhang X, He J, Xie Y, Chen Y. Sonic hedgehog promotes neurite outgrowth of cortical neurons under oxidative stress: Involving of mitochondria and energy metabolism.Exp Cell Res. 2017 Jan 1;350(1):83-90.

23. Tian H, Yao ST, Yang NN, Ren J, Jiao P, Zhang X, Li DX, Zhang GA, Xia ZF, Qin SC. D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-κB-dependent Fas/FasL pathway. Sci Rep. 2017 Aug 4;7(1):7333.)

24. Li Y, Zhang X, Cui L, Chen R, Zhang Y, Zhang C, Zhu X, He T, Shen Z, Dong L, Zhao J, Wen Y, Zheng X, Li P. Salvianolic Acids Enhance Cerebral Angiogenesis and Neurological Recovery by Activating JAK2/STAT3 Signaling Pathway after Ischemic Stroke in Mice. J Neuro chem. 2017 Oct;143(1):87-99.

25. Miao J, Wang L, Zhang X, Zhu C, Cui L, Ji H, Liu Y, Wang X. Protective Effect of Aliskiren in Experimental Ischemic Stroke: Up-Regulated p-PI3K, p-AKT, Bcl-2 Expression, Attenuated Bax Expression. Neurochem Res. 2016 Sep;41(9):2300-10.

26. Ye Zhang a; Xiangjian Zhang; Lili Cui a; Rong Chen a; Cong Zhang a; Yaoru Li a; Tingting He a; Xingyuan Zhu a; Zuyuan Shen a; Lipeng Dong a; Jingru Zhao a; Ya Wen a; Xiufen Zheng a; Pan Li. Salvianolic Acids for Injection (SAFI) Promotes Functional Recovery and Neurogenesis via Sonic Hedgehog Pathway after Stroke in Mice. Neurochem Int. 2017 Nov;110:38-48.

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